Pharmacokinetics of eicosapentaenoic acid in plasma and red blood cells after multiple oral dosing with AMR101 (ethyl­eicosapentaenoic acid) in healthy subjects

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman RA, Stirtan WG, Soni PN. Pharmacokinetics of eicosapentaenoic acid in plasma and red blood cells after multiple oral dosing with AMR101 (ethyl-eicosapentaenoic acid) in healthy subjects [abstract]. Presented at: Congress of the International Society for the Study of Fatty Acids and Lipids, Vancouver, Canada, May 26-30, 2012.

Effects of AMR101, a pure EPA omega­3 fatty acid, on the fatty acid profile in plasma and red blood cells in patients with very high triglycerides (results from the MARINE study)

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman RA, Manku MS, Bays HE, Stirtan WG, Soni PN. Effects of AMR101, a pure EPA omega-3 fatty acid, on the fatty acid profile in plasma and red blood cells in patients with very high triglycerides (results from the MARINE study) [abstract]. Presented at: Congress of the International Society for the Study of Fatty Acids and Lipids, Vancouver, Canada, May 26-30, 2012.

Effects of AMR101, a pure EPA omega­3 fatty acid, on the fatty acid profile in plasma and red blood cells in patients with very high triglycerides (results from the MARINE trial)

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman RA, Manku MS, Bays HE, Stirtan WG, Soni PN. Effects of AMR101, a pure EPA omega-3 fatty acid, on the fatty acid profile in plasma and red blood cells in patients with very high triglycerides (results from the MARINE trial) [abstract]. Eur Heart J. 2011;32(suppl 1):510-511.

AMR101, a pure­EPA omega­3 fatty acid, lowers triglycerides in patients with very high triglycerides without raising LDL­C: the MARINE study

Submitted by amarin on Fri, 12/08/2017 - 06:39

Bays HE, Ballantyne CM, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, Soni PN. AMR101, a pure-EPA omega-3 fatty acid, lowers triglycerides in patients with very high triglycerides without raising LDL-C: the MARINE study [abstract]. Eur Heart J. 2011;32(suppl 1):342.

Effects of AMR101 on lipid and inflammatory parameters in patients with diabetes mellitus­2 and residual elevated triglycerides (200­500 mg/dL) on statin therapy at LDL­C goal: the ANCHOR study

Submitted by amarin on Fri, 12/08/2017 - 06:39

Brinton EA, Ballantyne CM, Bays HE, Kastelein JJ, Braeckman RA, Soni PN. Effects of AMR101 on lipid and inflammatory parameters in patients with diabetes mellitus-2 and residual elevated triglycerides (200-500 mg/dL) on statin therapy at LDL-C goal: the ANCHOR study [abstract]. Eur Heart J. 2012;33(suppl 1):280.

Effects of AMR101, a pure ethyl eicosapentaenoic acid omega­3 fatty acid, on lipoprotein particle concentration and size in patients with very high triglycerides (the MARINE study)

Submitted by amarin on Fri, 12/08/2017 - 06:39

Bays HE, Braeckman RA, Ballantyne CM, Kastelein JJ, Otvos JD, Stirtan WG, Soni PN. Effects of AMR101, a pure ethyl eicosapentaenoic acid omega-3 fatty acid, on lipoprotein particle concentration and size in patients with very high triglycerides (the MARINE study) [abstract]. Circulation. 2011;124:A14232.

Effect of icosapent ethyl (eicosapentaenoic acid ethyl ester) on omeprazole plasma pharmacokinetics in healthy adults

Submitted by amarin on Fri, 12/08/2017 - 06:39

Braeckman RA, Stirtan WG, Soni PN. Effect of icosapent ethyl (eicosapentaenoic acid ethyl ester) on omeprazole plasma pharmacokinetics in healthy adults. Drugs R D. 2014;14:159-164.
Free:
http://link.springer.com/article/10.1007%2Fs40268-014-0053-9

AMR101 lowers triglycerides, atherogenic lipoprotein, phospholipase A2, and high­sensitivity C­ reactive protein levels in patients with high triglycerides and on background statin therapy (the ANCHOR study)

Submitted by amarin on Fri, 12/08/2017 - 06:39

Ballantyne CM, Bays HE, Kastelein JJ, Stein E, Isaacsohn JL, Braeckman RA, Soni PN. AMR101 lowers triglycerides, atherogenic lipoprotein, phospholipase A2, and high-sensitivity C- reactive protein levels in patients with high triglycerides and on background statin therapy (the ANCHOR study) [abstract]. Circulation. 2011;124:A15071.

Eicosapentaenoic acid inhibits glucose-­induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism.

Submitted by amarin on Fri, 12/08/2017 - 06:39

Mason RP, Jacob RF. Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism. Biochim Biophys Acta. 2015;1848:502-509.
Free:
http://dx.doi.org/10.1016/j.bbamem.2014.10.016